INTEGRATED CANCER THERAPY

Cancer Treatment

A Science-Driven Approach Combining Local Therapies & Immunotherapy

Cancer Treatment approach at SAISEI

Our clinic combines established and innovative immunotherapy techniques, including unique treatments like GcMAF therapy, developed through global research partnerships. We offer a range of scientifically-backed methods, tailored to each patient, that have proven effective alone or in combination. GcMAF therapy, a standout in our offerings, is gaining international acclaim based on extensive research and clinical trials. We provide access to a wealth of scientific literature on our website, highlighting our commitment to advancing medical knowledge and offering globally recognized treatments.

CLINICAL PHILOSOPHY

Concept of Cancer therapy at SAISEI

At SAISEI, we combine local tumor-targeted therapies with immunotherapy-based approaches to build an integrated treatment plan. By pairing methods that focus on the tumor site with therapies designed to support immune activity, we aim to create a balanced approach that prioritizes effectiveness while minimizing overall burden on the patient.

Teaching the adaptive immune system to see an antigen

LOCAL THERAPIES

Local tumor-targeted therapies

SDT Treatment (Sonodynamic Therapy)

Sonodynamic Therapy (SDT) uses low-intensity ultrasound to activate a sensitizing agent; the SDT mechanism presented in our overview describes ultrasound-triggered activation that can generate reactive oxygen species in tumor tissue and contribute to targeted cell damage.

The SDT overview also describes ultrasound cavitation concepts and energy release at the microscopic level.

Additionally, SDT is presented as a potential “whole body” concept with proposed targeting that may include primary and metastatic tumors as well as circulating/disseminated tumor cells.

HIFU Treatment

HIFU delivers high-intensity focused ultrasound to a targeted deep tissue area. At the focal point, it can rapidly raise tissue temperature to create coagulative necrosis. HIFU may also produce non-thermal effects such as cavitation.

What to expect

- A single session typically takes about 1 hour
- Anesthetic is usually not applied
- Can be used repeatedly
- Outpatient-style treatment

TTF Treatment

Tumor Treating Fields (TTF) is a non-invasive approach that uses low-intensity electric fields to help disrupt cancer cell division and may trigger apoptosis in dividing cells.

Saisei’s TTF system uses apparel plus an oscillator; many patients can use it while sleeping, supporting a consistent routine.

IMMUNOTHERAPY

Immunotherapy-based approaches

GcMAF Immunotherapy

An immunotherapy approach focused on macrophage activation, intended to support immune response mechanisms involved in recognizing and responding to abnormal cells.

GcMAF is a Gc protein-derived Macrophage Activating Factor used as part of SAISEI’s immunotherapy approach. It is available as Plasma GcMAF and Autologous GcMAF.

Originally developed for cancer treatment, GcMAF has shown effects across a wide range of immune-related and chronic conditions.

Naive T / NK cell therapy

Naive T / NK cell therapy uses peripheral blood–derived cells and is based on the concept that naive T cells are “stem cells of lymphocytes”.

In this approach, naive T cells, T cells, and NK cells are cultivated (typically ~14 days) to prepare an autologous product.

Key points:

Source: peripheral blood
Cells cultivated: naive T cells + T cells + NK cells
Process: ~14-day cultivation
Autologous product containing over 200 million cells
Registered medical procedure in Japan

Autologous cancer vaccine therapy

Personalized immunotherapy prepared from a patient’s own tumor tissue (formalin-fixed and, in some cases, paraffin-embedded) to stimulate immune recognition using tumor-associated antigens.

How it’s prepared (overview)

Prepared after surgery using more than 2 grams of tumor tissue
May be combined with immune-supporting adjuvants
Administered by injection under medical supervision

Dietary MAF

An oral MAF-based approach intended to support immune function and assist macrophage activity as part of overall wellness and immune regulation.

Dietary MAF is recognized not only for disease support, but also for its potential role in anti-aging and longevity through immune modulation.

P53 / PTEN Gene Therapy

A gene-therapy approach designed to address cancer-related genetic abnormalities by introducing tumor suppressor genes such as P53 (wild type) and PTEN.

Saisei’s approach uses plasmids and liposome-based delivery systems, aiming to support apoptosis, DNA repair, and cell-cycle regulation while reducing safety concerns associated with viral vectors.

P53: “guardian of the genome”
PTEN: regulator of cell growth and signaling
Non-viral liposome-based vector

SUPPORTIVE & INTEGRATIVE

Adjunct / supportive therapies

Coley Vaccine (Mixed Bacterial Vaccine) therapy

Also known as Coley’s Toxins / Coley Fluid (CF) — an immunotherapy approach originally developed by surgeon William Coley (1893). It uses a sterile preparation of inactivated bacteria to mimic a controlled immune stimulus.

Treatment overview

Typically given 3–5 times per week, aiming for 39.5–41°C body temperature, under qualified monitoring
Usually one infusion per day; ~5–6 hours per treatment day
Vital signs are continuously monitored by experienced medical staff
May be used alongside other immunotherapy approaches (e.g., GcMAF and Dietary MAF)

Low-dose option (Gentle Coley’s)

Lower doses with generally milder reactions and a shorter visit time (~1–2 hours)
Can be used before starting a regular Coley Vaccine protocol

High-Concentration Vitamin C IV (IVC) Therapy

High-dose intravenous vitamin C to reach blood levels that are difficult to achieve by oral intake.

Antioxidant support, cytokine-related inflammation regulation, collagen support
Pro-oxidant effect at pharmacologic concentrations (proposed targeted ROS mechanism)

Ozone Drip Therapy (Blood Cleansing / Major Autohemotherapy)

A small amount of blood is collected, mixed with a controlled dose of ozone, and returned to the body.

100–200 mL of blood is withdrawn
Ozone is mixed with the collected blood
The ozonated blood is reinfused

Hyperbaric Oxygen Chamber

Pressurized air (without supplemental oxygen) to gently increase surrounding pressure while you rest.

Supports fatigue recovery and conditioning
May support tissue oxygenation and recovery processes
Often positioned as wellness/anti-aging supportive therapy

Contact

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Clinic

Saisei Mirai

Address

9th floor, OMM Building, 1-7-31, Otemae, Chuo-ku, Osaka City, Osaka Prefecture, 540-0008

Phone

+81-06-6945-1551

Location

Osaka, Japan

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