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NEURODEVELOPMENT & IMMUNE SUPPORT

Autism Spectrum Disorder (ASD)

Physician-led consultation and individualized care planning.

Autism spectrum disorder is a serious neurodevelopmental disorder that impairs a child's ability to communicate and interact with others. It also includes restricted repetitive behaviors, interests and activities. These issues cause significant impairment in social, occupational and other areas of functioning. At Saisei Mirai, we provide a physician-led consultation and an individualized medical plan. Our approach may include immune-supportive strategies and discussion of MAF / GcMAF-based options as part of a broader care framework. We also emphasize coordination with your existing care team (pediatricians, psychiatrists, therapists, and educational support).

See the world through Autistic eyes. A video by The National Autistic Society of the UK.

Who may benefit from a consultation

Families and patients commonly contact us when they are looking for:
  • A structured, medical review of ASD-related challenges and goals
  • Support for day-to-day functioning (sleep, regulation, irritability, sensory issues, focus, fatigue patterns)
  • A physician-guided discussion of immune-focused support options, where appropriate
  • A plan coordinated alongside behavioral therapy, speech therapy, occupational therapy, and standard medical care
Rainbow
Clinic overview

Saisei Mirai: Clinical Approach & Philosophy

A short introduction to our medical perspective, research background, and how we approach individualized consultation for neurodevelopmental conditions.

Why we emphasize careful medical consultation

Neurodevelopmental conditions such as Autism Spectrum Disorder involve complex interactions between the nervous system, immune regulation, and individual developmental history. In this video, our team explains how we review clinical background, current therapies, and research context before discussing any immune-supportive strategies.
This video is intended for educational purposes and to support informed discussion — not as a substitute for personalized medical advice.

Our clinical perspective

Nature (2012): Microglia and synaptic pruning

Microglia: synaptic pruning

  • Once thought to be passive sentinels, microglia now seem to be crucial for pruning back neurons during development
  • Neurodevelopmental disorders such as autism and schizophrenia are often associated with faulty pruning
  • Mouse models of Obsessive Compulsive Disorder and Rett Syndrome, an autism spectrum disorder, show marked improvements after their microglia are replaced
Neuron (2014): Excess synapses and pruning slowdown

Microglia: synaptic pruning

New study finds that young people with autism have excess synapses in the brain. This excess is due to a slowdown in a normal brain “pruning” process during development. Synapses are the points where neurons connect and communicate with each other, and an excessive number of synapses may have profound effects on how the brain functions. A drug that restores normal synaptic pruning has been shown to improve autistic-like behaviors in mice, providing proof of concept.

Neuron (2014) 83: 1131–43

Targeting the Blood-Brain Barrier

The Blood–Brain Barrier appears to play a very important role in many diseases. Microglia are resident macrophages that patrol the brain and spinal cord for damaged cells and infectious agents. Microglia also may protect and repair the blood–brain barrier, including support of tight junction integrity. Malfunctioning or dysfunctional microglia could lead to neuroinflammation and a wide variety of brain diseases.
Microglia and blood–brain barrier illustration

Microglia and macrophages in brain homeostasis and disease

Microglia arise solely from yolk sac erythromyeloid precursors. Microglial precursors migrate to the brain parenchyma and quickly diverge from other tissue-resident macrophages in terms of their gene expression profile, under the influence of unknown brain-derived signals. During homeostasis, microglia maintain steady, region-specific densities by self-renewal. Microglia interact with almost all CNS components during embryonic and postnatal development, when they carry out a large number of non-immune tasks that are crucial for brain function. Microglia have multidimensional activation states in CNS diseases and injuries, such that these cells can have beneficial or detrimental roles depending on the context.
Nature Reviews Immunology cover (2018)
Nature Reviews Immunology, volume 18, pages 225–242 (2018)

What to expect at Saisei Mirai

MAF / GcMAF options in our framework
Our clinic materials describe multiple categories that may be discussed:
  • Plasma GcMAF
  • Autologous GcMAF (made from parent's blood)
  • Dietary MAF

Monitoring and follow-up

We do not publish individualized dosing schedules on public pages. If treatment is initiated, it is managed by a physician and adjusted based on tolerance and follow-up observations.

Consultation with child development specialist

What to bring to your visit

To help us evaluate your situation efficiently, please prepare:
  • Developmental / symptom timeline
  • Medications/supplements (current and recent past)
  • Prior evaluations and tests (reports, labs, imaging if any)
  • Vaccination and infection history (if relevant)
  • Current therapy plan (speech/OT/ABA or other) and any school/clinic reports
Visit preparation image
Evidence and Publications (selected)

Evidence and Publications (selected)

We believe it’s important to be transparent about the level of evidence behind different concepts discussed in ASD care and research.

References

  1. Inui T, Kumagaya S, Myowa-Yamakoshi M. Frontiers in Human Neuroscience. 2017;11:354. doi: 10.3389/fnhum.2017.00354. PMID: 28744208.
  2. Siniscalco D, Bradstreet JJ, et al. Journal of Neuroinflammation. 2014;11:78. doi: 10.1186/1742-2094-11-78. PMID: 24739187.
  3. Hughes V. Nature. 2012;485(7400):570–572. doi: 10.1038/485570a. PMID: 22660301.
  4. Tang G, et al. Neuron. 2014;83(5):1131–1143. doi: 10.1016/j.neuron.2014.07.040. PMID: 25155956.
  5. Inui T, et al. Anticancer Research. 2013;33(7):2917–2919. PMID: 23780980.
  6. Inui T, et al. Anticancer Research. 2016;36(7):3771–3774. PMID: 27354653.
  7. Inui T, et al. Anticancer Research. 2015;35(8):4545–4549. PMID: 26168499.
  8. Uto Y, et al. Anticancer Research. 2015;35(8):4487–4492. PMID: 26168491.
Contact

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    Clinic

    Saisei Mirai

    Address
    9th floor, OMM Building, 1-7-31, Otemae, Chuo-ku, Osaka City, Osaka Prefecture, 540-0008
    Phone
    +81-06-6945-1551
    Location
    Osaka, Japan
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