{"id":2954,"date":"2018-09-14T18:30:30","date_gmt":"2018-09-14T09:30:30","guid":{"rendered":"https:\/\/www.saisei-mirai.or.jp\/ssf\/?p=2954"},"modified":"2024-04-15T10:35:40","modified_gmt":"2024-04-15T01:35:40","slug":"sonophotodynamic_therapy","status":"publish","type":"post","link":"https:\/\/saisei-mirai.or.jp\/en\/sonophotodynamic_therapy\/","title":{"rendered":"Sonodynamic Therapy (SDT)"},"content":{"rendered":"\t\t
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Introduction to Sonodynamic Therapy\n(SDT)<\/h1>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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What is SDT?
\n\nHow does it work?
\n\nIs it safe?
\n\nIs it effective?\n<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Sonodynamic Therapy (SDT)\n<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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What is Sonodynamic Therapy?\n<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Sonodynamic therapy is a new cancer modality, which has huge potential in the treatment of cancer. Compared to photodynamic therapy (PDT), sonodynamic therapy has the advantage that ultrasound can penetrate deeply into the body. As you can see, we use low-intensity ultrasound to activate sensitizers in combination with ozone therapy or a hyperbaric oxygen chamber to increase oxygenation in cancer tissue.<\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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Equipment used for SDT \u2013 low intensity ultrasound (top) to activate sensitizer, ozone therapy or hyperbaric oxygen chamber to increase oxygenation <\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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\n\t\t\t\n\t\t\t\t\t\t\t\n\t\t\t\tIntroduction to Sonodynamic Therapy\t\t\t\t<\/span>\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Researchers collaborating with Saisei Mirai on SDT & PDT<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Saisei Mirai has been collaborating with researchers in different universities on sonodynamic therapy and GcMAF for many years (including Tokushima University, Tottori University, and Asahikawa University of Medicine).<\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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This experiment was conducted by Dr. Shibaguchi of Fukuoka University. Picture A and picture B both show ultrasound application to mice.<\/p>

You can see the changes in tumor size and tumor volume before SDT and after SDT.<\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t

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Introduction to Sonodynamic Therapy (SDT)\n<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Photo A) DCPH was used as a sonosensitizer
Photo B) DEG was used as a sonosensitizer<\/p>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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Sonodynamic therapy can be taken in a hot bath tub to target many cancer tissues in the body.\n<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Disseminated Tumor Cells (DTCs) and Circulating Tumor Cells (CTCs) - For a long time, bone marrow and the blood stream were suggested as cancer remaining places. Complete remission doesn\u2019t mean there are no cancer cells in the blood or in the bone marrow.\n<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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Sonodynamic therapy has been considered as a local treatment to destroy local cancer tissue. \nBut we may change this concept, because sonodynamic therapy can be taken in a hot bath tub as a whole body treatment. It can target primary tumors, both known and unknown, metastatic tumors, both known and unknown, circulating tumor cells in the blood and disseminated tumor cells in the bone marrow.\n<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Sonodynamic therapy (SDT) photosensitizers and sonosensitizers are basically non-toxic and are preferentially taken up by cancer cells.\u00a0The sensitizers are normally taken sublingually 24 hours prior to ultrasound application, but recently, we developed a new sonosensitizer which is taken by intravenous (IV) injection 1 hour prior to ultrasound application. Energy causes the activation of sonosensitizers, producing singlet oxygen and free-radical oxygen in cancer tissue, leading to coagulative necrosis. We usually combine SDT with GcMAF, which brings patients maximum treatment effects.\u00a0<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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What is Ultrasound cavitation?
Ultrasound is physical energy that causes ultrasound cavitation, that is, the formation of microbubbles when pressure is relatively low. This usually occurs when a liquid undergoes rapid changes in pressure\u2014alternating between high and low pressure. As the microbubbles increase in size and finally explode, they generate shock waves.\n\n<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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\nWhen microbubbles collapse in the microscopic world, they generate shock waves, high temperature of more than 5000 degrees Celsius, High pressure of more than 1000 atmospheric pressure and Strong light.\nWhen microbubbles don\u2019t collapse, they still generate ultrasonic microstreaming caused by vibrational size changes of microbubbles.\n<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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In H&E staining, tumors treated with ultrasound (US) and SDT showed ruptured blood vessels surrounded by pyknotic nuclei 24 hours after treatment. Necrotic cells were observed most commonly in tumors treated with SDT. Nuclei of tumor cells and tumor blood vessels were intact in the control and TONS504-Mn groups.
\n\nHistological changes after the treatment. \nIn Hematoxylin-eosin staining, tumors treated with ultrasound and SDT showed ruptured blood vessels surrounded by pyknotic nuclei 24 hours after treatment.\nNecrotic cells were observed most commonly in tumors treated with SDT.<\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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In Ki67 staining, Ki67-positive cells in the SDT group showed a significant decrease in number compared with other groups.
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SAISEI TREATMENTS <\/h2>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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\n\n GcMAF TREATMENT \n \n <\/h3>\n
\n GcMAF is a highly effective macrophage activating therapy, used to stimulate the immune system and activate macrophages so that they can destroy cancer cells and other abnormal cells in the body. <\/div>\n <\/div>\n\n
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\n \n \n \n Learn more <\/a>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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\n\n DIETARY MAF\n \n <\/h3>\n
\n Oral MAF therapy is employed to enhance the immune system and activate macrophages to assist the body in overcoming disease, thereby supporting and protecting the organism. <\/div>\n <\/div>\n\n
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\n \n \n \n Learn more <\/a>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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\n\n VITAMIN C\n \n <\/h3>\n
\n Intravenous high-dose Vitamin C treatment has antiviral and antibacterial effect and can be used as a supportive treatment to help the body to fight different infectious and viral diseases. <\/div>\n <\/div>\n\n
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\n \n \n \n Learn more <\/a>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\n <\/div>\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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<\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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\n

READY TO MAKE AN APPOINTMENT OR NEED MORE INFORMATION,<\/h2>

PLEASE CONTACT US<\/strong><\/p>CONTACT US<\/a>\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t

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<\/div>\n\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Reserch and Reports<\/h2>\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Case Report: A Breast Cancer Patient Treated with GcMAF, Sonodynamic Therapy and Hormone Therapy <\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t
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<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t
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Sonodynamic and Photodynamic Therapy in Advanced Breast Carcinoma<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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Activated Cancer Therapy Using Light and Ultrasound<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t
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Objective Outcome Measures Following Sonodynamic Photodynamic Therapy<\/figcaption>\n\t\t\t\t\t\t\t\t\t\t<\/figure>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"Introduction to Sonodynamic Therapy (SDT) What is SDT? How does it work? Is it safe? Is it effective? Sonodyna […]","protected":false},"author":1,"featured_media":5069,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"om_disable_all_campaigns":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"_uf_show_specific_survey":0,"_uf_disable_surveys":false,"site-sidebar-layout":"no-sidebar","site-content-layout":"default","ast-global-header-display":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"","footer-sml-layout":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","_themeisle_gutenberg_block_has_review":false},"categories":[37],"tags":[],"acf":[],"aioseo_notices":[],"_links":{"self":[{"href":"https:\/\/saisei-mirai.or.jp\/en\/wp-json\/wp\/v2\/posts\/2954"}],"collection":[{"href":"https:\/\/saisei-mirai.or.jp\/en\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/saisei-mirai.or.jp\/en\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/saisei-mirai.or.jp\/en\/wp-json\/wp\/v2\/users\/1"}],"replies":[{"embeddable":true,"href":"https:\/\/saisei-mirai.or.jp\/en\/wp-json\/wp\/v2\/comments?post=2954"}],"version-history":[{"count":70,"href":"https:\/\/saisei-mirai.or.jp\/en\/wp-json\/wp\/v2\/posts\/2954\/revisions"}],"predecessor-version":[{"id":12782,"href":"https:\/\/saisei-mirai.or.jp\/en\/wp-json\/wp\/v2\/posts\/2954\/revisions\/12782"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/saisei-mirai.or.jp\/en\/wp-json\/wp\/v2\/media\/5069"}],"wp:attachment":[{"href":"https:\/\/saisei-mirai.or.jp\/en\/wp-json\/wp\/v2\/media?parent=2954"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/saisei-mirai.or.jp\/en\/wp-json\/wp\/v2\/categories?post=2954"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/saisei-mirai.or.jp\/en\/wp-json\/wp\/v2\/tags?post=2954"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}