{"id":13990,"date":"2026-04-03T23:25:57","date_gmt":"2026-04-03T14:25:57","guid":{"rendered":"https:\/\/saisei-mirai.or.jp\/en\/?page_id=13990"},"modified":"2026-04-03T23:25:57","modified_gmt":"2026-04-03T14:25:57","slug":"research","status":"publish","type":"page","link":"https:\/\/saisei-mirai.or.jp\/en\/research\/","title":{"rendered":"Research"},"content":{"rendered":"

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NEUROIMMUNOLOGY & LONGEVITY<\/div>\r\n

Dementia, Kidney Health
& Biomarker Research<\/h1>\r\n

Premium, science-led overview of immune mechanisms and dietary MAF research.<\/p>\r\n

This page summarizes dementia background, a possible immune-supportive role of MAF capsules in brain function, chronic kidney disease basics, and an early mouse biomarker study measuring \u03b1-Klotho.<\/p>\r\n

Start Reading<\/a> Request Appointment<\/a><\/div>\r\n
Microglia<\/span> Inflammation<\/span> \u03b1-Klotho<\/span> Kidney health<\/span><\/div>\r\n<\/div>\r\n
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Research highlight<\/span><\/div>\r\n
\"Doctor<\/div>\r\n
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Science-led overview<\/div>\r\n
Neuro \u2022 Renal \u2022 Biomarkers<\/div>\r\n<\/div>\r\n<\/div>\r\n<\/div>\r\n<\/section>\r\n\r\n
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Dementia<\/div>\r\n

Understanding dementia as a syndrome<\/h2>\r\n<\/div>\r\n
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Dementia is a syndrome in which there is a decline in memory, thinking, behavior and the ability to carry out everyday activities. It is not a normal part of ageing, although it becomes more common as people get older. Worldwide, over 55 million people are living with dementia, and this number is expected to rise sharply in the coming decades.<\/p>\r\n

Dementia is a general term for these problems. Alzheimer\u2019s disease is the most common cause of dementia, but there are other types such as vascular dementia, Lewy body dementia and frontotemporal dementia.<\/p>\r\n

Premium note: dementia describes functional decline; causes may differ, but inflammation and waste-protein handling are recurring themes in research.<\/p>\r\n<\/div>\r\n\r\n

\"Scientific<\/div>\r\n<\/div>\r\n<\/div>\r\n<\/section>\r\n\r\n
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Mechanism<\/div>\r\n

How might MAF capsules support brain function?<\/h2>\r\n<\/div>\r\n
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MAF stands for Macrophage-Normalizing Factor. Macrophages are immune cells that act as the body\u2019s \u201cclean-up team\u201d, removing waste products, damaged cells, and abnormal proteins. In the brain, related cells called microglia play a similar role.<\/p>\r\n

Research suggests that, as we age, these immune cells may become less effective. This can contribute to a build-up of waste proteins (such as amyloid-\u03b2), increased inflammation, and gradual decline in memory and thinking.<\/p>\r\n

Laboratory and animal studies indicate that MAF can activate macrophages and may help regulate inflammation. In a small clinical study in elderly people attending a day-care rehabilitation facility, daily MAF capsules, together with simple dietary advice to reduce \u201cAGEs\u201d (advanced glycation end products), were associated with improved cognitive test scores over 6\u201312 months, compared with rehabilitation alone.<\/p>\r\n

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Concept<\/div>\r\n
\u201cClean-up\u201d function<\/div>\r\n
Waste proteins, damaged cells, abnormal proteins<\/div>\r\n<\/div>\r\n<\/div>\r\n
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Brain analogy<\/div>\r\n
Microglia<\/div>\r\n
Immune-like cells supporting tissue homeostasis<\/div>\r\n<\/div>\r\n<\/div>\r\n
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Lifestyle layer<\/div>\r\n
Reduce \u201cAGEs\u201d<\/div>\r\n
Dietary advice used alongside daily intake<\/div>\r\n<\/div>\r\n<\/div>\r\n<\/div>\r\n<\/div>\r\n<\/div>\r\n<\/section>\r\n\r\n
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Kidney health<\/div>\r\n

Chronic Kidney Disease<\/h2>\r\n<\/div>\r\n
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Chronic kidney disease (CKD) is a long-term (chronic) condition where the kidneys are damaged or not working as well as they should for at least 3 months. When kidneys don\u2019t filter blood properly, waste and extra fluid can build up in the body and lead to other health problems over time.<\/p>\r\n

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What causes CKD (most common)<\/div>\r\n
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The two most common causes in adults are:<\/p>\r\n

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  • Diabetes<\/li>\r\n
  • High blood pressure<\/li>\r\n<\/ul>\r\n

    Other things can also contribute (kidney inflammation, inherited conditions, certain medicines, etc.), but diabetes and high blood pressure are the big ones.<\/p>\r\n<\/div>\r\n<\/div>\r\n<\/div>\r\n\r\n

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